A new bufadienolide with cytotoxic activity from the Chinese traditional drug Ch'an Su / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 623-627, 2014.
Article
en En
| WPRIM
| ID: wpr-812224
Biblioteca responsable:
WPRO
ABSTRACT
AIM@#To study the bufadienolides in the Chinese traditional drug "Ch'an Su" and their cytotoxic activity.@*METHOD@#Various chromatographic techniques were used to isolate the constituents, and their structures were elucidated through physical and spectroscopic data.@*RESULTS@#Twenty compounds were isolated, and eighteen were evaluated in vitro for their cytotoxic activity against A-549 and K-562 cells.@*CONCLUSION@#Compound 1 (bufalin 3β-acrylic ester) was a new bufadienolide and exhibited the most potent activity against the two tumor cell lines with IC50 values of 7.16 and 6.83 nmol · L(-1). The relationships between structure and activity are discussed.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Productos Biológicos
/
Bufanólidos
/
Estructura Molecular
/
Química
/
Células K562
/
Concentración 50 Inhibidora
/
Usos Terapéuticos
/
Quimioterapia
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2014
Tipo del documento:
Article