Effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 94-96, 2006.
Article
en Zh
| WPRIM
| ID: wpr-813758
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the effects of aminoguanidine on the lung injury induced by the total hepatic ischemia-reperfusion in rats.@*METHODS@#The total hepatic ischemia-reperfusion model was built after blocking of the hepatic porta, suprahepatic and infrahepatic vena cava. Ninety Sprague-Dawley rats were assigned randomly into 3 groups Sham operation group (Group A, n=30); total hepatic ischemia group (Group B, n=30); and aminoguanidine treatment group (Group C, n=30). Each group was subdivided randomly into 3 subgroups (n=10) according to different time phases 20 minutes after the total hepatic vascular exclusion (T0), 4 hours after the reperfusion (T1), and 48 hours after the survival Group A and Group B were intravenously injected with normal saline ( mL/kg) while Group C was injected with aminoguanidine (20 mg/kg) dissolved in normal saline (1 mL/kg) 10 minutes before the open of the abdomin. The levels of portal blood nitric oxide ( O) endotoxin ( ET), tumor necrosis factor-alpha (TNF-alpha at T0 and T1 were detected; 48 hours survival rates and the lung wet/dry weight ratio were counted; and the histological changes of the lung tissues were observed.@*RESULTS@#Compared with Group A, the levels of portal vein NO, ET, and TNF-alpha T0 and T1 in Group B and Group C were significantly higher (P < 0.05 or P < 0.01). But those indexes of Group C were lower than those of Group B (P < 0.05). The 48-hour survival rate in Group C was higher than that in Group B (P < 0.05). The lung wet/dry weight ratio in Group C was lower than in Group B (P < 0.05) and the histological change of Group C was slighter than that in Group B.@*CONCLUSION@#Aminoguanidine has the protective effects on the lungs against the total hepatic ischemia-reperfusion induced injury.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
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Síndrome de Dificultad Respiratoria
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Daño por Reperfusión
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Distribución Aleatoria
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Ratas Sprague-Dawley
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Inhibidores Enzimáticos
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Óxido Nítrico Sintasa de Tipo II
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Guanidinas
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Hígado
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Central South University(Medical Sciences)
Año:
2006
Tipo del documento:
Article