Discovery of bioactive compounds and effector substance based on gut microbiota / 中草药

ABSTRACT

With the increase of the chronic complex diseases and the growing advantage of traditional Chinese medicine (TCM) in treating chronic complex diseases, Chinese materia media (CMM) became more and more importance in the world. However, the ambiguity of bioactive compounds, effective materials and their corresponding mechanisms has limited the acceptance of CMM in clinic and the internalization of CMM in the world. As a result, the discovery of bioactive compounds and effective materials that are directly associated with therapeutic effects of CMM is one of the most important scientific question in researching of CMM. Hence, in this article, we briefly reviewed current methods for discovery of bioactive compounds and effective materials. Then, with references related to the international research frontier and the characteristics of CMM ingredients, according to the characteristics of most Chinese medicine through oral administration, combined with the previous research basis of our research group, a research model that is based on gut microbiota was investigated to discover bioactive compounds and effective materials. The aim of this research model is to provide new thoughts on discovery of new drugs, the mechanism study of CMM, etc., and eventually promote the modernization and internalization of CMM.