Optimal separation and purification of extract in Sanao Sustained-release Tablets with macroporous resins by multi index comprehensive score / 中草药
Chinese Traditional and Herbal Drugs
; (24): 255-261, 2016.
Article
en Zh
| WPRIM
| ID: wpr-853757
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To explore the optimal separation and purification of extract in Sanao Sustained-release Tablets.Methods:
Taking the adsorption ratio and desorption ratio of ephedrine hydrochloride, pseudoephedrine hydrochloride, amygdalin, and glycyrrhizinate as evaluation indexes to optimize the purification process of Sanao Sustained-release Tablets by multi index comprehensive score.Results:
Macroporous resin HPD 300 had the best adsorption and desorption properties. In the course of adsorption, the optimum concentration of the sample liquid was 1.67 g crude drugs of per milliliter, the resin column size ratio was 1 7, the concentration of sample solution was 0.6 g/mL crude drug, the sample flow rate was 4.0 BV/h. In the course of elution, 2 BV deionized water was used and the resin column chromatography was eluted with 5 BV of 70% EtOH by flow rate of 3 BV/h.Conclusion:
Macroporous resin HPD 300 is suitable to separate and purify the extract from Sanao Sustained-release Tablets.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Traditional and Herbal Drugs
Año:
2016
Tipo del documento:
Article