Determination method of dynamic viscosity of methylcellulose / 中国药学杂志

ABSTRACT

OBJECTIVE: To solve the existing problems of the determination method of dynamic viscosity of methylcellulose in Chinese Pharmacopoeia (2010 edition) METHODS: By virtue of concentric cylinder rheometer, the experiment probes into the influence of shear rate, temperature measurement, the yield value, thixotropic, etc. on the rheological properties of samples, and identifies then the optimum temperature and shear rate of the samples. RESULTS: The optimum conditions were established as temperature of (20±0.1)°C and shear rate of 80 s-1. CONCLUSION: This method is simple and accurate with good repeatability. It can be applied to determine the viscosity of methylcellulose.