Efficacy of Short-Term Growth Hormone Treatment in Prepubertal Children with Idiopathic Short Stature
Yonsei Medical Journal
; : 53-60, 2014.
Article
en En
| WPRIM
| ID: wpr-86941
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
It has been reported that daily recombinant human growth hormone (GH) treatment showed beneficial effects on growth in prepubertal children with idiopathic short stature (ISS). The present study aimed to validate the GH (Eutropin(R)) effect on growth promotion and safety after short-term GH treatment. MATERIALS ANDMETHODS:
This study was an open-label, multicenter, interventional study conducted at nine university hospitals in Korea between 2008 and 2009. Thirty six prepubertal children with ISS were enrolled in this study to receive 6-month GH treatment. Yearly growth rate, height standard deviation score (SDS), and adverse events were investigated during treatment.RESULTS:
After 26 weeks of GH treatment, the height velocity significantly increased by 6.36+/-3.36 cm/year (p<0.001). The lower end of one-sided 95% confidence interval was 5.22 cm/year, far greater than the predefined effect size. The gain in height SDS at week 26 was 0.57+/-0.27 (p<0.0001). Bone age significantly increased after GH treatment, however, bone maturation rate (bone age for chronological age) showed limited advancement. This 26-week GH treatment was effective in increasing serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 from baseline (p<0.0001). Eutropin was well tolerated and there were no withdrawals due to adverse events. No clinically significant changes in laboratory values were observed.CONCLUSION:
This 6-month daily GH treatment in children with ISS demonstrated increased height velocity, improved height SDS, and increased IGF-I and IGFBP-3 levels with a favorable safety profile.Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Factor I del Crecimiento Similar a la Insulina
/
Hormona del Crecimiento
/
Resultado del Tratamiento
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Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina
/
Trastornos del Crecimiento
Tipo de estudio:
Clinical_trials
Límite:
Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Yonsei Medical Journal
Año:
2014
Tipo del documento:
Article