Antimicrobial peptides: bridging innate and adaptive immunity in the pathogenesis of psoriasis / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2966-2975, 2020.
Article
en En
| WPRIM
| ID: wpr-877923
Biblioteca responsable:
WPRO
ABSTRACT
Antimicrobial peptides (AMPs) are small molecules produced by a myriad of cells and play important roles not only in protecting against infections and sustaining skin barrier homeostasis but also in contributing to immune dysregulation under pathological conditions. Recently, increasing evidence has indicated that AMPs, including cathelicidin (LL-37), human β-defensins, S100 proteins, lipocalin 2, and RNase 7, are highly expressed in psoriatic skin lesions. These peptides broadly regulate immunity by interacting with various immune cells and linking innate and adaptive immune responses during the progression of psoriasis. In this review, we summarize the recent findings regarding AMPs in the pathogenesis of psoriasis with a main focus on their immunomodulatory abilities.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Psoriasis
/
Enfermedades de la Piel
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Beta-Defensinas
/
Proteínas Citotóxicas Formadoras de Poros
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Inmunidad Adaptativa
/
Inmunidad Innata
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Año:
2020
Tipo del documento:
Article