Regulatory roles of microRNAs in sarcopenia and exercise intervention / 生理学报
Acta Physiologica Sinica
; (6): 667-676, 2020.
Article
en Zh
| WPRIM
| ID: wpr-878212
Biblioteca responsable:
WPRO
ABSTRACT
Sarcopenia is an age-related degenerative disease, in which skeletal muscle mass and function are reduced during aging process. Physical intervention is one of the most effective strategies available for the treatment of sarcopenia. Studies have shown that microRNAs (miRNAs), as important regulators of gene expression, play an important role in maintaining the homeostasis of senescent skeletal muscle cells by regulating skeletal muscle cell development (proliferation and differentiation), mitochondrial biogenesis, protein synthesis and degradation, inflammatory response and metabolic pathways. Furthermore, exercise can combat age-related changes in muscle mass, composition and function, which is associated with the changes in the expression and biological functions of miRNAs in skeletal muscle cells. In this article, we systematically review the regulatory mechanisms of miRNAs in skeletal muscle aging, and discuss the regulatory roles and molecular targets of exercise-mediated miRNAs in muscular atrophy during aging process, which may provide novel insights into the prevention and treatment of sarcopenia.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Envejecimiento
/
Músculo Esquelético
/
MicroARNs
/
Terapia por Ejercicio
/
Sarcopenia
Tipo de estudio:
Systematic_reviews
Límite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2020
Tipo del documento:
Article