Effects of delivery and storage conditions on concentrations of amino acids and carnitines in neonatal dried blood spots / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 565-573, 2020.
Article
en Zh
| WPRIM
| ID: wpr-879913
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore effects of different delivery and storage conditions on concentrations of amino acids and carnitines in neonatal dried blood spots (DBS), so as to provide evidence for improving accurate and reliable detection by tandem mass spectrometry.@*METHODS@#A total of 1 254 616 newborn DBS samples in Newborn Screening Center of Zhejiang Province were delivered and stored at room temperature (group A, @*RESULTS@#The concentrations of amino acids and carnitines in the three groups were skewed, and the differences in amino acid and carnitine concentrations among groups were statistically significant (all @*CONCLUSIONS@#Cold-chain logistics system and storage in low temperature and low humidity can effectively reduce degradation of some amino acids and carnitines in DBS, improve the accuracy and reliability of detection, and thus ensures the quality of screening for neonatal metabolic diseases.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Manejo de Especímenes
/
Temperatura
/
Factores de Tiempo
/
Carnitina
/
Reproducibilidad de los Resultados
/
Tamizaje Neonatal
/
Espectrometría de Masas en Tándem
/
Pruebas con Sangre Seca
/
Aminoácidos
/
Humedad
Límite:
Humans
/
Newborn
Idioma:
Zh
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2020
Tipo del documento:
Article