Gene Mutation in Acute Lymphoblastic Leukemia by DNA Sequencing / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1791-1795, 2020.
Article
en Zh
| WPRIM
| ID: wpr-879973
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To analyze the characteristics of gene mutation in adult ALL and its clinical significance.@*METHODS@#Clinical data of 134 primary adult ALL patients and DNA sequencing results of 16 kinds of gene mutation were collected. The characteristic of gene mutation and clinical significances were statistically analyzed.@*RESULTS@#In 31 cases of 134 ALL cases (23.13%) the gene mutations were detected as follows: 19 cases of 114 B-ALL cases (16.67%), 11 cases of 19 T-ALL cases (57.89%) and 1 case of T/B-ALL. The incidence of T-ALL gene mutation was significantly higher than that of B-ALL (χ@*CONCLUSION@#There may be multiple gene mutations in adult ALL patients. IL7R and NOTCH1 are the most common gene mutations and NOTCH1 mutation may indicate poor prognosis. Detection of gene mutations is helpful to understand the pathogenesis of ALL and evaluate the prognosis of adult ALL patients.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
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Análisis de Secuencia de ADN
/
Receptor Notch1
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Leucemia-Linfoma Linfoblástico de Células T Precursoras
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Mutación
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2020
Tipo del documento:
Article