Progress in Gene Therapy of Sickle Cell Disease Based on Hemoglobin F--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 643-647, 2021.
Article
en Zh
| WPRIM
| ID: wpr-880127
Biblioteca responsable:
WPRO
ABSTRACT
Sickle cell disease (SCD) is a single gene genetic disease, which seriously threatens the life span and quality of patients. On the basis of the pathogenesis of SCD and the alternative therapy based on fetal hemoglobin F (HbF), the research progress of transcription factors involved in the regulation of HbF gene expression, such as BCL11A, ZBTB7A, KLF-1, c-MYB and SOX6, as well as the application of CRISPR / Cas9, TALEN, zinc finger nuclease and other gene editing technologies in this field has been made, providing a solid theoretical basis for the exploration of new treatment schemes for β- like hemoglobin diseases, such as sickle cell disease and β- thalassemia.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Proteínas Represoras
/
Factores de Transcripción
/
Hemoglobina Fetal
/
Terapia Genética
/
Línea Celular Tumoral
/
Proteínas de Unión al ADN
/
Anemia de Células Falciformes
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2021
Tipo del documento:
Article