HIF / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 333-344, 2021.
Article
en En
| WPRIM
| ID: wpr-880664
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES@#To analyze the expressions and distributions of hypoxia-inducible factor-1α (HIF-1α), CD147, and glucose transporter 1 (GLUT1) in epidermis from psoriasis vulgaris and normal people, and to explore the associations among these proteins and their roles in hypoxic HaCaT cell line.@*METHODS@#The expression levels of HIF-1α, CD147, and GLUT1 were determined by immunohistochemistry staining in skin biopsies from 48 psoriasis vularis patients and 33 healthy subjects. Cobalt chloride (CoCl@*RESULTS@#HIF-1α, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1α upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl@*CONCLUSIONS@#Glycolytic capacity increases in the injured keratinocytes of psoriasis vulgaris, suggesting that HIF-1α, CD147, and GLUT1 are associated with glycolysis, which can be considered as the promising targets for psoriasis therapy.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Psoriasis
/
Activación Transcripcional
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Regulación hacia Arriba
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Transportador de Glucosa de Tipo 1
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Subunidad alfa del Factor 1 Inducible por Hipoxia
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Basigina
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Glucólisis
Límite:
Humans
Idioma:
En
Revista:
Journal of Central South University(Medical Sciences)
Año:
2021
Tipo del documento:
Article