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Study on the secondary metabolites of grasshopper-derived fungi Arthrinium sp. NF2410 / 中国天然药物
Article en En | WPRIM | ID: wpr-881042
Biblioteca responsable: WPRO
ABSTRACT
Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives, arthrianhydride A (1) and B (2), along with three known compounds 3-5, were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium sp. NF2410. The structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic data. Furthermore, compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.
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Texto completo: 1 Base de datos: WPRIM Asunto principal: Productos Biológicos / Estructura Molecular / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Metabolismo Secundario / Hongos / Saltamontes / Anhídridos Límite: Animals Idioma: En Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2020 Tipo del documento: Article Pais de publicación: CHINA / CN / REPUBLIC OF CHINA
Texto completo: 1 Base de datos: WPRIM Asunto principal: Productos Biológicos / Estructura Molecular / Inhibidores Enzimáticos / Proteína Tirosina Fosfatasa no Receptora Tipo 11 / Metabolismo Secundario / Hongos / Saltamontes / Anhídridos Límite: Animals Idioma: En Revista: Chinese Journal of Natural Medicines (English Ed.) Año: 2020 Tipo del documento: Article Pais de publicación: CHINA / CN / REPUBLIC OF CHINA