A smart MnO
Acta Pharmaceutica Sinica B
; (6): 823-834, 2021.
Article
en En
| WPRIM
| ID: wpr-881171
Biblioteca responsable:
WPRO
ABSTRACT
The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic modality. However, tumor is pathologically featured with extreme hypoxia together with the adaptable overexpression of anti-oxidants, such as glutathione (GSH), which greatly restricts the therapeutic efficiency. Here, a combinatorial strategy was designed to simultaneously relieve tumor hypoxia by self-oxygenation and reduce intracellular GSH level to sensitize chemo-photodynamic therapy. In our system, a novel multi-functional nanosystem based on MnO
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Base de datos:
WPRIM
Idioma:
En
Revista:
Acta Pharmaceutica Sinica B
Año:
2021
Tipo del documento:
Article