Research status and prospect of basic application of islet organoid / 器官移植
Organ Transplantation
; (6): 397-2021.
Article
en Zh
| WPRIM
| ID: wpr-881523
Biblioteca responsable:
WPRO
ABSTRACT
Organoids are tissue structures, generated from pluripotent stem cells and cultured in vitro, which form self-organize and recapitulate tissues with similar structure and function to the original organs. Organoids have similar appearance and function to the original tissues, and have been widely applied in basic research and clinical trial. At present, the organoids of liver, kidney, islet, brain, intestine and other organs have been successfully cultivated. The use of islet organoid is a hotspot in the field of organoid research. However, islet organoid is currently applied in basic research because rejection after organ transplantation and other issues remain unresolved. In this article, the origin, development and basic application of islet organoid were reviewed, aiming to provide reference for the transformation from basic research of islet organoid into clinical application as well as the treatment of diabetes mellitus.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
Organ Transplantation
Año:
2021
Tipo del documento:
Article