Research progress of new tumor imaging agent 68Ga-FAPIs / 中华核医学与分子影像杂志

ABSTRACT

18F-fluorodeoxyglucose (FDG) is the most commonly used broad-spectrum tumor imaging agent, but there are certain limitations in the application of some tumors. Fibroblast activation protein (FAP) is selectively expressed in more than 90% of malignant epithelial tumors, while it is hardly expressed in normal tissues and benign tumors. FAP inhibitors (FAPIs) specifically bind to FAP and selectively target FAP-positive tissues. In recent years, it has been reported that radionuclide-labeled FAPIs, such as 68Ga-FAPIs, are safe and reliable in tumor imaging and have low tissue background. They can also be used to image a variety of solid tumors, which are expected to be new tumor broad-spectrum imaging agents and play a greater role in clinical applications. This article reviews the recent progress of FAPIs in tumor imaging and diagnosis at home and abroad.