Serotype Distribution of Invasive Group B Streptococcal Diseases in Infants at Two University Hospitals in Korea
Pediatric Infection & Vaccine
; : 79-86, 2017.
Article
en Ko
| WPRIM
| ID: wpr-89168
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: This study was aimed at analyzing the serotypes of group B streptococcus (GBS) isolated from Korean infants with invasive disease and evaluating their association with disease manifestation. METHODS: Data were retrospectively collected from invasive GBS infections at Gachon University Gil Medical Center from January 2006 to June 2012 and at Samsung Medical Center from April 2010 to November 2012. Serotypes were determined by slide agglutination test. RESULTS: A total of 37 cases were identified, which included 22 full-term infants and 15 preterm infants. Fifteen cases (40.5%) were early-onset, 19 (51.4%) was late-onset, and three (8.1%) was very late-onset. Early-onset diseases among preterm infants were higher than those among full-term infants (60.0% [9/15] vs. 27.3% [6/22], P =0.17). The most common manifestation was bacteremia (70.3%), followed by meningitis and septic arthritis. Among 24 isolates retrievable for serotyping, serotype III (41.7%) was most common, followed by V (16.7%), Ia, Ib, and II (12.5%, respectively), and non-typeable (4.2%). Serotype III was more common in isolates from full-term infants (10/22) than from preterm infants (0/15), whereas serotype V was more common in isolates from preterm infants (4/15) than from full-term infants (0/22) (P =0.002). No penicillin-resistant strain was detected, and resistance to erythromycin and clindamycin were both 64.9%. CONCLUSIONS: GBS is an important pathogen in both preterm and full-term infants, and serotype distribution of GBS causing invasive diseases can differ between preterm and full-term infants. It is necessary to monitor the nationwide epidemiology of GBS diseases, including in preterm infants, in order to prepare preventive measures without underestimating early-onset diseases.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Streptococcus
/
Streptococcus agalactiae
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Recien Nacido Prematuro
/
Pruebas de Aglutinación
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Clindamicina
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Artritis Infecciosa
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Serotipificación
/
Eritromicina
/
Epidemiología
/
Estudios Retrospectivos
Tipo de estudio:
Observational_studies
Límite:
Humans
/
Infant
/
Newborn
País/Región como asunto:
Asia
Idioma:
Ko
Revista:
Pediatric Infection & Vaccine
Año:
2017
Tipo del documento:
Article