Progress of MICB/NKG2D signaling pathway in immune escape / 国际儿科学杂志
International Journal of Pediatrics
; (6): 584-588, 2021.
Article
en Zh
| WPRIM
| ID: wpr-907283
Biblioteca responsable:
WPRO
ABSTRACT
Natural killer group 2 member D(NKG2D) is an immune receptor expressed by NK cells that recognizes the human major histocompatibility complex class I polypetide-related chain(MIC) A/B on the cell surface.The interaction between NKG2D and MICA/B plays an important role in the immunosurveillance of viruses infection and cancers.In this article, we review the research progress of the MICB/NKG2D signaling pathway in immune escape including three parts: down-regulation of membrane-bound MICB, increase of secretory MICB, and polymorphism of MICB genes.
Texto completo:
1
Base de datos:
WPRIM
Idioma:
Zh
Revista:
International Journal of Pediatrics
Año:
2021
Tipo del documento:
Article