Effect of high-fat diet for rats at different stages on glucose and lipid metabolism in offspring and related mechanisms / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1174-1183, 2021.
Article
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| WPRIM
| ID: wpr-922407
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVES@#To study the effect of high-fat diet for maternal Sprague-Dawley rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.@*METHODS@#According to the diet before pregnancy and during pregnancy and lactation, maternal rats were randomly divided into four groups (@*RESULTS@#Compared with the control diet groups (CC and CH groups), the groups with high-fat diet before pregnancy (HC and HH groups) had a significant increase in body weight (@*CONCLUSIONS@#High-fat diet for rats at different stages before and after pregnancy has different effects on glucose and lipid metabolism of offspring rats, and high-fat diet before pregnancy and during pregnancy and lactation has the greatest effect. The effect of high-fat diet on glucose and lipid metabolism of offspring rats is considered associated with the changes in the expression of genes involved in glucose and lipid metabolism.
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Texto completo:
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Base de datos:
WPRIM
Asunto principal:
Peso Corporal
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Resistencia a la Insulina
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Ratas Sprague-Dawley
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Metabolismo de los Lípidos
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Dieta Alta en Grasa
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Glucosa
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Insulina
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Hígado
Límite:
Animals
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Pregnancy
Idioma:
En
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2021
Tipo del documento:
Article