An Autopsy Confirmed Case of Amyotrophic Lateral Sclerosis with TDP Pathology
Journal of the Korean Neurological Association
; : 164-167, 2022.
Article
en Ko
| WPRIM
| ID: wpr-926299
Biblioteca responsable:
WPRO
ABSTRACT
The phosphorylated 43-kDa transactive response DNA-binding protein (TDP-43) was identified as a major disease protein in sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration. We present a case with progressive muscle weakness who was diagnosed with sporadic ALS. On postmortem examination, TDP-43 immunoreactive neuronal cytoplasmic inclusions were noted in motor cortex, hippocampus and anterior horns of spinal cord, which was compatible with ALS-TDP, stage 4. This is the first documented autopsy-confirmed ALS case with ALS-TDP pathology in Korea.
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1
Base de datos:
WPRIM
Idioma:
Ko
Revista:
Journal of the Korean Neurological Association
Año:
2022
Tipo del documento:
Article