Oxidosqualene cyclases in triterpenoids biosynthesis: a review / 生物工程学报
Chinese Journal of Biotechnology
; (12): 443-459, 2022.
Article
en Zh
| WPRIM
| ID: wpr-927721
Biblioteca responsable:
WPRO
ABSTRACT
Triterpenoids are one of the most diverse compounds in plant metabolites, and they have a wide variety of physiological activities and are of important economic value. Oxidosqualene cyclases catalyze the cyclization of 2, 3-oxidosqualene to generate different types of sterols and plant triterpenoids, which is of great significance to the structural diversity of natural products. However, the mechanism of the diversified cyclization of 2, 3-oxidosqualene catalyzed by oxidosqualene cyclases remains unclear. This review summarized the research progress of oxidosqualene cyclases from the aspects of catalytic function, molecular evolutionary relationship between genes and proteins, protein structure, molecular simulation and molecular calculations, which may provide a reference for protein engineering and metabolic engineering of triterpene cyclase.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Plantas
/
Escualeno
/
Triterpenos
/
Transferasas Intramoleculares
/
Ingeniería Metabólica
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Año:
2022
Tipo del documento:
Article
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA