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Oxidosqualene cyclases in triterpenoids biosynthesis: a review / 生物工程学报
Chinese Journal of Biotechnology ; (12): 443-459, 2022.
Article en Zh | WPRIM | ID: wpr-927721
Biblioteca responsable: WPRO
ABSTRACT
Triterpenoids are one of the most diverse compounds in plant metabolites, and they have a wide variety of physiological activities and are of important economic value. Oxidosqualene cyclases catalyze the cyclization of 2, 3-oxidosqualene to generate different types of sterols and plant triterpenoids, which is of great significance to the structural diversity of natural products. However, the mechanism of the diversified cyclization of 2, 3-oxidosqualene catalyzed by oxidosqualene cyclases remains unclear. This review summarized the research progress of oxidosqualene cyclases from the aspects of catalytic function, molecular evolutionary relationship between genes and proteins, protein structure, molecular simulation and molecular calculations, which may provide a reference for protein engineering and metabolic engineering of triterpene cyclase.
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Texto completo: 1 Base de datos: WPRIM Asunto principal: Plantas / Escualeno / Triterpenos / Transferasas Intramoleculares / Ingeniería Metabólica Idioma: Zh Revista: Chinese Journal of Biotechnology Año: 2022 Tipo del documento: Article Pais de publicación: CHINA / CN / REPUBLIC OF CHINA
Texto completo: 1 Base de datos: WPRIM Asunto principal: Plantas / Escualeno / Triterpenos / Transferasas Intramoleculares / Ingeniería Metabólica Idioma: Zh Revista: Chinese Journal of Biotechnology Año: 2022 Tipo del documento: Article Pais de publicación: CHINA / CN / REPUBLIC OF CHINA