Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 155-160, 2022.
Article
en En
| WPRIM
| ID: wpr-929246
Biblioteca responsable:
WPRO
ABSTRACT
Three new ursane-type triterpenoids, 3-oxours-12-en-20, 28-olide (1), 3β-hydroxyurs-12-en-20, 28-olide (2) and 3β-hydroxyurs-11, 13(18)-dien-20, 28-olide (3), were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic extract of Rosmarinus officinalis. Their structures were elucidated by a combination of extensive 1D- and 2D-NMR experiments, MS data and comparisons with literature reports. Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages, but no antibacterial activity was found at a concentration of 128 μg·mL-1.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Triterpenos
/
Medicamentos Herbarios Chinos
/
Estructura Molecular
/
Rosmarinus
Límite:
Animals
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2022
Tipo del documento:
Article