Primary ovarian squamous cell carcinoma: clinicopathological features and prognostic analysis of fifteen cases / 中华病理学杂志
Chinese Journal of Pathology
; (12): 332-337, 2022.
Article
en Zh
| WPRIM
| ID: wpr-935535
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To assess the clinical features and treatment outcomes in patients with primary ovarian squamous cell carcinoma (POSCC).Methods:
Fifteen patients with primary ovarian squamous cell carcinoma diagnosed from January 2009 to December 2018 in Cancer Hospital of the University of Chinese Academy of Sciences were collected. The expression of p16, hMLH1, hMSH2, hMSH6 and PMS2 in POSCC was detected by immunohistochemistry, and the status of high-risk human papillomavirus (HPV) by RNAscope test.Results:
Squamous cell carcinoma with different degrees of differentiation was found in 15 cases, including three cases with high differentiation and 12 cases with medium to low differentiation. There were four cases with in situ squamous cell carcinoma, four cases with teratoma, one case with endometrial carcinoma/atypical hyperplasia, and one case with endometriosis. p16 was expressed in five cases (5/15), indicating coexisting high-risk HPV infection. There was no high-risk HPV infection in the remaining 10 cases, and p16 staining was negative. There was no deficient mismatch repair protein in all cases. The overall survival time (P=0.038) and progression free survival (P=0.045) of patients with high-risk HPV infection were longer than those without HPV infection.Conclusions:
POSCC is more commonly noted in postmenopausal women and often occurs unilaterally. Elevated serological indexes CA125 and SCC are the most common finding. Morphologically, the tumors show variable degrees of differentiation, but the current data suggest that the degree of differentiation cannot be used as an independent prognostic index. High-risk HPV infection may be associated with the occurrence of POSCC, and that the prognosis of POSCC patients with HPV infection is better than that of patients without infection.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Pronóstico
/
Inmunohistoquímica
/
Carcinoma de Células Escamosas
/
Inhibidor p16 de la Quinasa Dependiente de Ciclina
/
Infecciones por Papillomavirus
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
Idioma:
Zh
Revista:
Chinese Journal of Pathology
Año:
2022
Tipo del documento:
Article
Pais de publicación:
CHINA
/
CN
/
REPUBLIC OF CHINA