Down-regulated expression of NPM1 in IMS-M2 cell line by (-)-epigallocatechin-3-gallate
Asian Pacific Journal of Tropical Biomedicine
; (12): 570-574, 2014.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-951915
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To investigate the inhibited effect of epigallocatechin-3-gallate (EGCG) on the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations.Methods:
Cell proliferation assay was performed to test the effects of EGCG on cell growth of IMS-M2 cells harboring the NPM1 mutations. Western blot analysis were performed to test the protein expression of NPM1, AKT, those associated with apoptosis.Results:
EGCG can down-regulate the expression of NPM1 in IMS-M2 cells harboring the NPM1 mutations. Moreover, EGCG also suppressed the cell proliferation and induced apoptosis in IMS-M2 cells.Conclusions:
The results suggested that EGCG could be considered as a reagent for treatment of AML patients with NPM1 mutations.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2014
Tipo del documento:
Artículo