Immunomodulatory activity of polysaccharides from Brassica rapa by activating Akt/NF-κB signaling / 中草药·英文版
Chinese Herbal Medicines
; (4): 90-96, 2022.
Article
en Zh
| WPRIM
| ID: wpr-953614
Biblioteca responsable:
WPRO
ABSTRACT
Objective:
To investigate the immunomodulatory activity of polysaccharides from the roots of Brassica rapa.Methods:
The crude polysaccharide from roots of B. rapa (BRP) was extracted and purified to further investigate the active fraction of BRT for inducing macrophage phagocytosis.Results:
Effects on RAW264.7 cells demonstrated that BRP behaved better phagocytic capacity and had potent immunomodulatory activity, including increasing production of nitric oxide (NO), tumor necrosis factor α (TNFα) and upregulating mRNA levels of inducible NO synthase (iNOS) and TNFα. Furthermore, modulation of macrophage by BRP was indicated to be mediated via the activation of Akt and nuclear factor-kappa B (NF-κB).Conclusion:
The beneficial effects of BRP could be used as an immunotherapeutic adjuvant in treatment of inflammatory diseases.
Texto completo:
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Herbal Medicines
Año:
2022
Tipo del documento:
Article