Your browser doesn't support javascript.
loading
Research progress in high mobility group box-1 in hypoxic-ischemic brain damage / 中华围产医学杂志
Article en Zh | WPRIM | ID: wpr-958121
Biblioteca responsable: WPRO
ABSTRACT
Inflammation plays an important part in neonatal hypoxic-ischemic brain damage (HIBD). High mobility group box-1 protein (HMGB1), a neuroinflammatory trigger, has a dual effect on HIBD in the acute stage, it amplifies the ischemic tissue injury; in the later stage, it is involved in the neurovascular repair and reconstruction. The significance of HMGB1 in the pathogenesis of HIBD is still not fully understood. This review summarizes the role of HMGB1 in HIBD, including its effects on neurons, glial cells and blood-brain barrier, and the underlying mechanisms as well as the progress in research on HMGB1 in immature brain, hoping to provide new ideas for neuroprotection in HIBD.
Palabras clave
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Journal of Perinatal Medicine Año: 2022 Tipo del documento: Article
Texto completo: 1 Base de datos: WPRIM Idioma: Zh Revista: Chinese Journal of Perinatal Medicine Año: 2022 Tipo del documento: Article