Morroniside Inhibits Hydrogen Peroxide-induced Calcium Overload and Cytotoxicity in SH-SY5Y Neuroblastoma Cells / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
; (12): 201-202, 2009.
Article
en Zh
| WPRIM
| ID: wpr-964520
Biblioteca responsable:
WPRO
ABSTRACT
@# Objective To investigate the effects of morroniside on hydrogen peroxide (H2O2)-induced calcium overload and cytotoxicity in SH-SY5Y neuroblastoma cells. Methods SH-SY5Y cells were pre-incubated with morroniside 1, 10, or 100 μmol/L for 24 h prior to exposure to H2O2 300~500 μmol/L for 18 h. The cytosolic free calcium concentration and LDH release were determined. Results The H2O2-induced cytosolic free calcium concentration decreased in the cells pre-incubated with morroniside 10 or 100 μmol/L, while the LDH release level decreased in the cells pre-incubated with morroniside 1, 10 or 100 μmol/L, comparison with the cells exposed H2O2 along. Conclusion Morroniside effects neuroprotection against H2O2-induced calcium overload and cytotoxicity in SH-SY5Y cell.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Año:
2009
Tipo del documento:
Article