Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 425-439, 2023.
Article
en En
| WPRIM
| ID: wpr-971574
Biblioteca responsable:
WPRO
ABSTRACT
Chronic pain is challenging to treat due to the limited therapeutic options and adverse side-effects of therapies. Astrocytes are the most abundant glial cells in the central nervous system and play important roles in different pathological conditions, including chronic pain. Astrocytes regulate nociceptive synaptic transmission and network function via neuron-glia and glia-glia interactions to exaggerate pain signals under chronic pain conditions. It is also becoming clear that astrocytes play active roles in brain regions important for the emotional and memory-related aspects of chronic pain. Therefore, this review presents our current understanding of the roles of astrocytes in chronic pain, how they regulate nociceptive responses, and their cellular and molecular mechanisms of action.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Neuroglía
/
Astrocitos
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Enfermedad Crónica
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Transmisión Sináptica
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Dolor Crónico
/
Neuronas
Límite:
Humans
Idioma:
En
Revista:
Neuroscience Bulletin
Año:
2023
Tipo del documento:
Article