Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 3-18, 2023.
Article
en En
| WPRIM
| ID: wpr-971661
Biblioteca responsable:
WPRO
ABSTRACT
Type I interferon (IFN) is considered as a bridge between innate and adaptive immunity. Proper activation or inhibition of type I IFN signaling is essential for host defense against pathogen invasion, tumor cell proliferation, and overactive immune responses. Due to intricate and diverse chemical structures, natural products and their derivatives have become an invaluable source inspiring innovative drug discovery. In addition, some natural products have been applied in clinical practice for infection, cancer, and autoimmunity over thousands of years and their promising curative effects and safety have been well-accepted. However, whether these natural products are primarily targeting type I IFN signaling and specific molecular targets involved are not fully elucidated. In the current review, we thoroughly summarize recent advances in the pharmacology researches of natural products for their type I IFN activity, including both agonism/activation and antagonism/inhibition, and their potential application as therapies. Furthermore, the source and chemical nature of natural products with type I IFN activity are highlighted and their specific molecular targets in the type I IFN pathway and mode of action are classified. In conclusion, natural products possessing type I IFN activity represent promising therapeutic strategies and have a bright prospect in the treatment of infection, cancer, and autoimmune diseases.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Productos Biológicos
/
Transducción de Señal
/
Interferón Tipo I
/
Inmunidad Innata
Idioma:
En
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2023
Tipo del documento:
Article