Correlation of RUNX3 expression with microvessel density in colorectal adenocarcinoma tissues and clinical significance
Asian Pacific Journal of Tropical Medicine
; (12): 98-101, 2017.
Article
en Zh
| WPRIM
| ID: wpr-972693
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the expression of RUNX3 in colorectal adenocarcinoma tissues and its correlation with microvessel density (MVD), and investigate the clinical pathological prognostic significance of RUNX3 and MVD in patients with colorectal cancer. Methods The expression value of RUNX3 and MVD in 70 specimens’ colorectal adenocarcinoma tissues were detected by immunohistochemistry staining technique. The correlation between their expression and the clinicopathologic features was also investigated. Results The expression value of RUNX3 and the positive rates of RUNX3 in colorectal adenocarcinoma tissues were 3.25 ± 1.14 and 25.71% (18/70). The expression value of MVD in colorectal adenocarcinoma tissues was 13.14 ± 3.23. Expression of RUNX3 and MVD value were correlated with CEA, serosal invasion, liver metastasis, lymph node metastasis, and TNM stage (P < 0.01). The expression value of RUNX3 had negative correlations with that of MVD. Conclusions The high expression of RUNX3 could inhibit tumor microvascular generation in order to have negative control response on invasion and distant metastasis.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2017
Tipo del documento:
Article