Different expression of TNF-alpha in brain and peripheral organs after cerebral contusion of rats / 法医学杂志
Journal of Forensic Medicine
; (6): 261-264, 2012.
Article
en Zh
| WPRIM
| ID: wpr-983745
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#To compare the expression of tumor necrosis factor-alpha (TNF-alpha) between brain and peripheral organs after cerebral contusion in order to provide the scientific theoretical basis for forensic pathological diagnosis and wound age estimation.@*METHODS@#Brain and peripheral organs including heart, liver, spleen, lung, kidney tissues of 45 SD rats after the cerebral contusion were obtained and TNF-alpha of these tissues were analyzed with immunohistochemistry methods.@*RESULTS@#TNF-alpha was detected at 1 h in brain, reaching maximum at 6 h and 3 d after the cerebral contusion, and then decreased but still kept at high expression level at 7 d. TNF-alpha was detected at 1 h after the cerebral contusion in heart, liver, spleen, lung and kidney tissues. The number of cells expressing TNF-alpha increased gradually, reaching maximum at 3 d after the contusion of brain, and then decreased but still kept at high expression level at 7 d.@*CONCLUSION@#Besides the change of cerebral contusion, this study considered both the brain and peripheral organs. It is helpful for forensic pathological diagnosis and wound age estimation after contusion of brain.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Bazo
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Encéfalo
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Lesiones Encefálicas
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Inmunohistoquímica
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Distribución Tisular
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Factor de Necrosis Tumoral alfa
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Ratas Sprague-Dawley
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Contusiones
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Modelos Animales de Enfermedad
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Riñón
Límite:
Animals
Idioma:
Zh
Revista:
Journal of Forensic Medicine
Año:
2012
Tipo del documento:
Article