Research advance of mesenchymal stem cell-derived exosomes in graft-versus-host disease / 中华器官移植杂志
Chinese Journal of Organ Transplantation
; (12): 377-382, 2023.
Article
en Zh
| WPRIM
| ID: wpr-994681
Biblioteca responsable:
WPRO
ABSTRACT
Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewing differentiation, immunoactivity and anti-inflammatory potentials.Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the most effective treatment for hematologic malignancies.However, the presence of graft-versus-host disease (GVHD) after transplantation has hindered the development of allo-HSCT.MSC-derived exosomes (MSC-exo) derived from mesenchymal stem cells have been confirmed to have broad therapeutic prospects in allo-HSCT and GVHD.This review focused upon immunomodulatory effects of MSC, biological activities of MSC-exo and research advances of MSC-exo on managing GVHD, aiming to provide new therapeutic rationales for GVHD in the future.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Organ Transplantation
Año:
2023
Tipo del documento:
Article