Giant perianal condyloma successfully treated with podophyllin at 25% in solid petrolatum
J. coloproctol. (Rio J., Impr.)
; 41(3): 289-294, July-Sept. 2021. tab, ilus
Article
in En
| LILACS
| ID: biblio-1346420
Responsible library:
BR545.3
ABSTRACT
Purpose:
Giant perianal condyloma (GPC) is a rare condition. The effective treatment is a multidisciplinary challenge; topical treatments are usually ineffective, and surgical resection has significant morbidity. Podophyllin at 25% in solid petrolatum (25%PSP) can be an effective treatment option for GPC. The aim of the present study was to assess its response and tolerability.Methods:
This retrospective, single-center case series evaluated the clinical response of 14 patients with GPC treated with 25%PSP in a public hospital in Buenos Aires between December 2015 and December 2019. After obtaining a full history and performing a physical exam, the lesions were measured and photographed. Biopsies were performed to exclude malignancy, as well as exams to rule out pregnancy. Podophyllin at 25% in solid petrolatum was administered topically in cases of GPC and washed off by the patients at home after 4 hours. The patients underwent at least 4 weekly visits, which included interval history, photodocumentation of the lesions, and provider-applied 25%PSP. The response rate was assessed by comparingmeasurements and the overall decrease in volume of the GPC based on photos from the first and last sessions. Adverse outcomes were noted.Results:
In total, 10 men, 3 women, and 1 transgender woman with GPC unresponsive to prior treatments and a mean age of 34.5 years were included. A total of 12 patients were immunosuppressed. All the perianal lesions were circumferential and measured between 8 cm and 20 cm. Overall, 7 patients had genital condyloma outside of the anus and perianus; the histology showed low-grade squamous intraepithelial lesions in all cases. While on treatment, 7 patients reported dermatitis, and 71% of the patients had 75% reduction in lesion size.Conclusions:
Podophyllin at 25% in solid petrolatum is an effective, well-tolerated topical treatment option for GPC. (AU)Key words
Full text:
1
Collection:
01-internacional
Database:
LILACS
Main subject:
Podophyllin
/
Dermatitis
Limits:
Adolescent
/
Adult
/
Female
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Humans
/
Male
Language:
En
Journal:
J. coloproctol. (Rio J., Impr.)
Journal subject:
Cirurgia
/
Doenas Retais
/
Doenas do Colo
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GASTROENTEROLOGIA
/
Cirurgia
Year:
2021
Document type:
Article
Affiliation country:
/