Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.

Palanki, Moorthy S S; Akiyama, Hideo; Campochiaro, Peter; Cao, Jianguo; Chow, Chun P; Dellamary, Luis; Doukas, John; Fine, Richard; Gritzen, Colleen; Hood, John D; Hu, Steven; Kachi, Shu; Kang, Xinshan; Klebansky, Boris; Kousba, Ahmed; Lohse, Dan; Mak, Chi Ching; Martin, Michael; McPherson, Andrew; Pathak, Ved P; Renick, Joel; Soll, Richard; Umeda, Naoyasu; Yee, Shiyin; Yokoi, Katsutoshi; Zeng, Binqi; Zhu, Hong; Noronha, Glenn

Palanki, Moorthy S S; Akiyama, Hideo; Campochiaro, Peter; Cao, Jianguo; Chow, Chun P; Dellamary, Luis; Doukas, John; Fine, Richard; Gritzen, Colleen; Hood, John D; Hu, Steven; Kachi, Shu; Kang, Xinshan; Klebansky, Boris; Kousba, Ahmed; Lohse, Dan; Mak, Chi Ching; Martin, Michael; McPherson, Andrew; Pathak, Ved P; Renick, Joel; Soll, Richard; Umeda, Naoyasu; Yee, Shiyin; Yokoi, Katsutoshi; Zeng, Binqi; Zhu, Hong; Noronha, Glenn.

Affiliation

Palanki MS; TargeGen Inc., 9890 Judicial Drive, San Diego, CA 92121, USA. Palanki@targegen.com

J Med Chem ; 51(6): 1546-59, 2008 Mar 27.

Article in En | MEDLINE | ID: mdl-18311895

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ophthalmic Solutions / Phenols / Triazines / Prodrugs / Macular Degeneration Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Document type: Article Affiliation country: Country of publication:

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