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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Li, Lian-Sheng; Zhou, Yuefen; Murphy, Douglas E; Stankovic, Nebojsa; Zhao, Jingjing; Dragovich, Peter S; Bertolini, Thomas; Sun, Zhongxiang; Ayida, Benjamin; Tran, Chinh V; Ruebsam, Frank; Webber, Stephen E; Shah, Amit M; Tsan, Mei; Showalter, Richard E; Patel, Rupal; Lebrun, Laurie A; Bartkowski, Darian M; Nolan, Thomas G; Norris, Daniel A; Kamran, Ruhi; Brooks, Jennifer; Sergeeva, Maria V; Kirkovsky, Leo; Zhao, Qiang; Kissinger, Charles R.
Affiliation
  • Li LS; Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, CA 92121, USA.
Bioorg Med Chem Lett ; 18(11): 3446-55, 2008 Jun 01.
Article in En | MEDLINE | ID: mdl-18457949
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyridazines / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Hepacivirus Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Pyridazines / RNA-Dependent RNA Polymerase / Viral Nonstructural Proteins / Hepacivirus Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Country of publication: