The case for hypervirulence through gene deletion in Mycobacterium tuberculosis.
Trends Microbiol
; 16(9): 436-41, 2008 Sep.
Article
in En
| MEDLINE
| ID: mdl-18701293
ABSTRACT
Deletion of genes in a pathogen is commonly associated with a reduction in its ability to cause disease. However, some rare cases have been described in the literature whereby deletion of a gene results in an increase in virulence. Recently, there have been several reports of hypervirulence resulting from gene deletion in Mycobacterium tuberculosis. Here, we explore this phenomenon in the context of the interaction between the pathogen and the host response.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tuberculosis, Pulmonary
/
Gene Deletion
/
Mycobacterium tuberculosis
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2008
Document type:
Article
Affiliation country: