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Type 17 T-helper cells might be a promising therapeutic target for osteoporosis.
Yuan, Feng-Lai; Li, Xia; Lu, Wei-Guo; Zhao, Yi-Qing; Li, Cheng-Wan; Li, Jian-Ping; Sun, Jun-Ming; Xu, Rui-Sheng.
Affiliation
  • Yuan FL; Central Laboratory, The Third Hospital Affiliated to Nantong University, Wuxi, 214041, Jiangsu, China. bjjq88@163.com
Mol Biol Rep ; 39(1): 771-4, 2012 Jan.
Article in En | MEDLINE | ID: mdl-21556758
Osteoporosis, a disease characterized by low bone mass and deterioration of bone tissue, is a pressing public health problem. Recent studies have suggested a possible role of T-helper (Th) cells in the pathogenesis of bone loss which occurs in systemic inflammatory diseases. However, there are contradictions in the published literature regarding the functional role of Th1/Th2 cells in the regulation of the differentiation of osteoclasts. These paradoxes have now been clarified by the recent discovery of Th17 cells, a novel subset of Th cells that selectively secrete several proinflammatory cytokines, mainly IL-17. It has been confirmed that Th17 cells have stimulatory effects on osteoclastogenesis and accelerate bone loss in animal models with inflammatory disorders. Targeting Th17 cells or IL-17 may inhibit the bone resorption with RA. Thus, we are led to suppose that Th17 cells might be promising therapeutic targets in osteoporosis.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Osteoporosis / Bone Resorption / Cell Differentiation / Th17 Cells / Models, Biological Limits: Humans Language: En Journal: Mol Biol Rep Year: 2012 Document type: Article Affiliation country: Country of publication:

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoclasts / Osteoporosis / Bone Resorption / Cell Differentiation / Th17 Cells / Models, Biological Limits: Humans Language: En Journal: Mol Biol Rep Year: 2012 Document type: Article Affiliation country: Country of publication: