Branched-chain amino acid requirements for enterally fed term neonates in the first month of life.
Am J Clin Nutr
; 99(1): 62-70, 2014 Jan.
Article
in En
| MEDLINE
| ID: mdl-24284437
ABSTRACT
BACKGROUND:
Knowledge of essential amino acid requirements in infants is important because excessive intake of protein can lead to increased long-term morbidity such as obesity. A deficient intake may lead to suboptimal growth and impaired neurodevelopment. The current recommended branched-chain amino acid requirements in infants aged 0-1 mo are based on the amino acid content of human milk.OBJECTIVE:
We quantified the requirements for isoleucine, leucine, and valine for term neonates by using the indicator amino acid oxidation method with [1-(13)C]phenylalanine as the indicator.DESIGN:
Fully enterally fed term infants received randomly graded amounts of isoleucine (5-216 mg · kg(-1) · d(-1)), leucine (5-370 mg · kg(-1) · d(-1)), or valine (5-236 mg · kg(-1) · d(-1)) as part of an elemental formula. Data are expressed as means ± SDs.RESULTS:
Eighty-three Asian, term neonates (mean ± SD birth weight 3.3 ± 0.4 kg; gestational age 39.4 ± 1.3 wk) were studied at a postnatal age of 13 ± 5 d. Mean requirements for isoleucine, leucine, and valine (measured in boys only) were 105 mg · kg(-1) · d(-1) (r(2) = 0.61, P < 0.001), 140 mg · kg(-1) · d(-1) (r(2) = 0.26, P < 0.01), and 110 mg · kg(-1) · d(-1) (r(2) = 0.35, P = 0.001), respectively.CONCLUSIONS:
Current human milk-based recommendations for isoleucine and valine in term infants aged 0-1 mo are correct. However, the current recommendation for leucine (166 mg · kg(-1) · d(-1)) is higher than the mean requirement of 140 mg · kg(-1) · d(-1) that we determined in this study. This trial was registered at www.trialregister.nl as NTR1610.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Amino Acids, Branched-Chain
/
Infant Nutritional Physiological Phenomena
/
Nutritional Requirements
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
Am J Clin Nutr
Year:
2014
Document type:
Article