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Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.
Seki, Hajime; Pellett, Sabine; Silhár, Peter; Stowe, G Neil; Blanco, Beatriz; Lardy, Matthew A; Johnson, Eric A; Janda, Kim D.
Affiliation
  • Seki H; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
  • Pellett S; Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, WI 53706, United States.
  • Silhár P; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
  • Stowe GN; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
  • Blanco B; Centro Singular de Investigación en Química Biológica y Materiales Moleculares (CIQUS), Universidad de Santiago de Compostela, calle Jenaro de la Fuente s/n, 15782 Santiago de Compostela, Spain.
  • Lardy MA; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States.
  • Johnson EA; Department of Bacteriology, University of Wisconsin, 1550 Linden Drive, Madison, WI 53706, United States.
  • Janda KD; Departments of Chemistry and Immunology, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, United States; Worm Institute for Research and Medicine (WIRM), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jol
Bioorg Med Chem ; 22(3): 1208-17, 2014 Feb 01.
Article in En | MEDLINE | ID: mdl-24360826
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Prodrugs / Botulinum Toxins, Type A / Small Molecule Libraries / Hydroxamic Acids Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Prodrugs / Botulinum Toxins, Type A / Small Molecule Libraries / Hydroxamic Acids Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Document type: Article Affiliation country: