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Fitness costs of rifampicin resistance in Mycobacterium tuberculosis are amplified under conditions of nutrient starvation and compensated by mutation in the ß' subunit of RNA polymerase.
Song, Taeksun; Park, Yumi; Shamputa, Isdore Chola; Seo, Sunghwa; Lee, Sun Young; Jeon, Han-Seung; Choi, Hongjo; Lee, Myungsun; Glynne, Richard J; Barnes, S Whitney; Walker, John R; Batalov, Serge; Yusim, Karina; Feng, Shihai; Tung, Chang-Shung; Theiler, James; Via, Laura E; Boshoff, Helena I M; Murakami, Katsuhiko S; Korber, Bette; Barry, Clifton E; Cho, Sang-Nae.
Affiliation
  • Song T; International Tuberculosis Research Center, Changwon, South Korea.
Mol Microbiol ; 91(6): 1106-19, 2014 Mar.
Article in En | MEDLINE | ID: mdl-24417450
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / DNA-Directed RNA Polymerases / Mycobacterium smegmatis / Mutation, Missense / Drug Resistance, Bacterial / Antitubercular Agents Type of study: Health_economic_evaluation Language: En Journal: Mol Microbiol Journal subject: BIOLOGIA MOLECULAR / MICROBIOLOGIA Year: 2014 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rifampin / DNA-Directed RNA Polymerases / Mycobacterium smegmatis / Mutation, Missense / Drug Resistance, Bacterial / Antitubercular Agents Type of study: Health_economic_evaluation Language: En Journal: Mol Microbiol Journal subject: BIOLOGIA MOLECULAR / MICROBIOLOGIA Year: 2014 Document type: Article Affiliation country: Country of publication: