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Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.
Chonghaile, Triona Ni; Roderick, Justine E; Glenfield, Cian; Ryan, Jeremy; Sallan, Stephen E; Silverman, Lewis B; Loh, Mignon L; Hunger, Stephen P; Wood, Brent; DeAngelo, Daniel J; Stone, Richard; Harris, Marian; Gutierrez, Alejandro; Kelliher, Michelle A; Letai, Anthony.
Affiliation
  • Chonghaile TN; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Roderick JE; Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
  • Glenfield C; Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland.
  • Ryan J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Sallan SE; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
  • Silverman LB; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
  • Loh ML; Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, California.
  • Hunger SP; Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
  • Wood B; Department of Medicine, University of Washington, Seattle, Washington.
  • DeAngelo DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Stone R; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Harris M; Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
  • Gutierrez A; Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
  • Kelliher MA; Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts. anthony_letai@dfci.harvard.edu michelle.kelliher@umassmed.edu.
  • Letai A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. anthony_letai@dfci.harvard.edu michelle.kelliher@umassmed.edu.
Cancer Discov ; 4(9): 1074-87, 2014 Sep.
Article in En | MEDLINE | ID: mdl-24994123
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Drug Resistance, Neoplasm / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 / Bcl-X Protein / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Discov Year: 2014 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Drug Resistance, Neoplasm / Bridged Bicyclo Compounds, Heterocyclic / Proto-Oncogene Proteins c-bcl-2 / Bcl-X Protein / Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Antineoplastic Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Discov Year: 2014 Document type: Article Country of publication: