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Statin-Induced Myopathy Is Associated with Mitochondrial Complex III Inhibition.
Schirris, Tom J J; Renkema, G Herma; Ritschel, Tina; Voermans, Nicol C; Bilos, Albert; van Engelen, Baziel G M; Brandt, Ulrich; Koopman, Werner J H; Beyrath, Julien D; Rodenburg, Richard J; Willems, Peter H G M; Smeitink, Jan A M; Russel, Frans G M.
Affiliation
  • Schirris TJ; Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Renkema GH; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Ritschel T; Computational Discovery and Design Group, Center for Molecular and Biomolecular Informatics (CMBI), Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Voermans NC; Department of Neurology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Bilos A; Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • van Engelen BG; Department of Neurology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Brandt U; Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Koopman WJ; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Department of Biochemistry, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Beyrath JD; Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Rodenburg RJ; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Willems PH; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Department of Biochemistry, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Smeitink JA; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Nijmegen Center for Mitochondrial Disorders, Department of Pediatrics, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands.
  • Russel FG; Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands; Center for Systems Biology and Bioenergetics, Nijmegen Center for Mitochondrial Disorders, Radboud University Medical Center, Nijmegen 6500HB, the Netherlands. Electronic address: frans.ru
Cell Metab ; 22(3): 399-407, 2015 Sep 01.
Article in En | MEDLINE | ID: mdl-26331605
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Electron Transport Complex III / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Myoblasts / Lactones / Mitochondria / Muscular Diseases Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2015 Document type: Article Affiliation country: Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Electron Transport Complex III / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Myoblasts / Lactones / Mitochondria / Muscular Diseases Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Humans Language: En Journal: Cell Metab Journal subject: METABOLISMO Year: 2015 Document type: Article Affiliation country: Country of publication: