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Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity.
Mahlangu, J N; Weldingh, K N; Lentz, S R; Kaicker, S; Karim, F A; Matsushita, T; Recht, M; Tomczak, W; Windyga, J; Ehrenforth, S; Knobe, K.
Affiliation
  • Mahlangu JN; Haemophilia Comprehensive Care Centre, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg, South Africa.
  • Weldingh KN; Novo Nordisk A/S, Bagsvaerd, Denmark.
  • Lentz SR; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.
  • Kaicker S; Maimonides Medical Centre, New York, NY, USA.
  • Karim FA; Haemophilia Centre, National Blood Centre, Kuala Lumpur, Malaysia.
  • Matsushita T; Department of Transfusion Medicine, Nagoya University Hospital, Nagoya, Japan.
  • Recht M; Hemophilia Center, Oregon Health and Science University, Portland, OR, USA.
  • Tomczak W; Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland.
  • Windyga J; Department of Disorders of Haemostasis and Internal Medicine, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
  • Ehrenforth S; Novo Nordisk A/S, Bagsvaerd, Denmark.
  • Knobe K; Novo Nordisk A/S, Bagsvaerd, Denmark.
J Thromb Haemost ; 13(11): 1989-98, 2015 Nov.
Article in En | MEDLINE | ID: mdl-26362483
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor VIIa / Amino Acid Substitution / Isoantibodies Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Thromb Haemost Journal subject: HEMATOLOGIA Year: 2015 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor VIIa / Amino Acid Substitution / Isoantibodies Type of study: Clinical_trials / Etiology_studies / Risk_factors_studies Limits: Humans Language: En Journal: J Thromb Haemost Journal subject: HEMATOLOGIA Year: 2015 Document type: Article Affiliation country: Country of publication: