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DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
Harris, Philip A; King, Bryan W; Bandyopadhyay, Deepak; Berger, Scott B; Campobasso, Nino; Capriotti, Carol A; Cox, Julie A; Dare, Lauren; Dong, Xiaoyang; Finger, Joshua N; Grady, LaShadric C; Hoffman, Sandra J; Jeong, Jae U; Kang, James; Kasparcova, Viera; Lakdawala, Ami S; Lehr, Ruth; McNulty, Dean E; Nagilla, Rakesh; Ouellette, Michael T; Pao, Christina S; Rendina, Alan R; Schaeffer, Michelle C; Summerfield, Jennifer D; Swift, Barbara A; Totoritis, Rachel D; Ward, Paris; Zhang, Aming; Zhang, Daohua; Marquis, Robert W; Bertin, John; Gough, Peter J.
Affiliation
  • Grady LC; Platform Technology & Science, GlaxoSmithKline , Winter Street, Waltham, Massachusetts 02451, United States.
  • Summerfield JD; Platform Technology & Science, GlaxoSmithKline , Winter Street, Waltham, Massachusetts 02451, United States.
  • Zhang A; Platform Technology & Science, GlaxoSmithKline , King of Prussia, Pennsylvania 19406, United States.
J Med Chem ; 59(5): 2163-78, 2016 Mar 10.
Article in En | MEDLINE | ID: mdl-26854747
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / DNA / Protein Kinase Inhibitors / Receptor-Interacting Protein Serine-Threonine Kinases / Small Molecule Libraries / Isoxazoles Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxazepines / DNA / Protein Kinase Inhibitors / Receptor-Interacting Protein Serine-Threonine Kinases / Small Molecule Libraries / Isoxazoles Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2016 Document type: Article Country of publication: