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Fasiglifam (TAK-875) has dual potentiating mechanisms via Gαq-GPR40/FFAR1 signaling branches on glucose-dependent insulin secretion.
Sakuma, Kensuke; Yabuki, Chiori; Maruyama, Minoru; Abiru, Akiko; Komatsu, Hidetoshi; Negoro, Nobuyuki; Tsujihata, Yoshiyuki; Takeuchi, Koji; Habata, Yugo; Mori, Masaaki.
Affiliation
  • Sakuma K; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Yabuki C; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Maruyama M; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Abiru A; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Komatsu H; Central Nervous System Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Negoro N; Inflammation Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Tsujihata Y; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Takeuchi K; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Habata Y; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
  • Mori M; Cardiovascular and Metabolic Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Fujisawa Kanagawa Japan.
Pharmacol Res Perspect ; 4(3): e00237, 2016 Jun.
Article in En | MEDLINE | ID: mdl-27433346
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmacol Res Perspect Year: 2016 Document type: Article Country of publication:
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharmacol Res Perspect Year: 2016 Document type: Article Country of publication: