Pre-metastatic niches: organ-specific homes for metastases.
Nat Rev Cancer
; 17(5): 302-317, 2017 05.
Article
in En
| MEDLINE
| ID: mdl-28303905
ABSTRACT
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neoplasm Metastasis
/
Neoplasms
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Rev Cancer
Journal subject:
NEOPLASIAS
Year:
2017
Document type:
Article
Affiliation country: