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Dual Targeting of Oncogenic Activation and Inflammatory Signaling Increases Therapeutic Efficacy in Myeloproliferative Neoplasms.
Kleppe, Maria; Koche, Richard; Zou, Lihua; van Galen, Peter; Hill, Corinne E; Dong, Lauren; De Groote, Sofie; Papalexi, Efthymia; Hanasoge Somasundara, Amritha V; Cordner, Keith; Keller, Matthew; Farnoud, Noushin; Medina, Juan; McGovern, Erin; Reyes, Jaime; Roberts, Justin; Witkin, Matthew; Rapaport, Franck; Teruya-Feldstein, Julie; Qi, Jun; Rampal, Raajit; Bernstein, Bradley E; Bradner, James E; Levine, Ross L.
Affiliation
  • Kleppe M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Koche R; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Zou L; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • van Galen P; Department of Pathology Massachusetts General Hospital, Harvard Medical School, Broad Institute of Harvard and MIT, Boston, MA, USA.
  • Hill CE; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • Dong L; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • De Groote S; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • Papalexi E; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • Hanasoge Somasundara AV; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • Cordner K; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • Keller M; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.
  • Farnoud N; Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Medina J; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • McGovern E; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Reyes J; Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
  • Roberts J; Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
  • Witkin M; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Rapaport F; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Teruya-Feldstein J; Department of Pathology, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
  • Qi J; Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.
  • Rampal R; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Bernstein BE; Department of Pathology Massachusetts General Hospital, Harvard Medical School, Broad Institute of Harvard and MIT, Boston, MA, USA.
  • Bradner JE; Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. Electronic address: james.bradner@novartis.com.
  • Levine RL; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA; Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Center for Hematologic Malignancies, Memorial Sloan Kettering Cancer C
Cancer Cell ; 33(1): 29-43.e7, 2018 01 08.
Article in En | MEDLINE | ID: mdl-29249691
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Protein Kinase Inhibitors / Inflammation / Myeloproliferative Disorders Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Country of publication:
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Protein Kinase Inhibitors / Inflammation / Myeloproliferative Disorders Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Cell Journal subject: NEOPLASIAS Year: 2018 Document type: Article Affiliation country: Country of publication: