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Penicillixanthone A, a marine-derived dual-coreceptor antagonist as anti-HIV-1 agent.
Tan, Suiyi; Yang, Bin; Liu, Juan; Xun, Tianrong; Liu, Yonghong; Zhou, Xuefeng.
Affiliation
  • Tan S; a Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science , South Medical University , Guangzhou , China.
  • Yang B; b Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology, CAS , Guangzhou , China.
  • Liu J; b Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology, CAS , Guangzhou , China.
  • Xun T; a Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Science , South Medical University , Guangzhou , China.
  • Liu Y; b Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology, CAS , Guangzhou , China.
  • Zhou X; b Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-Resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica , South China Sea Institute of Oceanology, CAS , Guangzhou , China.
Nat Prod Res ; 33(10): 1467-1471, 2019 May.
Article in En | MEDLINE | ID: mdl-29258357
ABSTRACT
Marine micro-organisms have been proven to be excellent sources of bioactive compounds against HIV-1. Several natural products obtained from marine-derived Aspergillus fungi were screened for their activities to inhibit HIV-1 infection. Penicillixanthone A (PXA), a natural xanthone dimer from jellyfish-derived fungus Aspergillus fumigates, displayed potent anti-HIV-1 activity by inhibiting infection against CCR5-tropic HIV-1 SF162 and CXCR4-tropic HIV-1 NL4-3, with IC50 of 0.36 and 0.26 µM, respectively. Molecular docking study was conducted to understand the possible binding mode of PXA with the CCR5/CXCR4. The results revealed that, the marine-derived PXA, as a CCR5/CXCR4 dual-coreceptor antagonist, presents a new type of potential lead product for the development of anti-HIV therapeutics.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-HIV Agents / Receptors, CCR5 / Xanthones / CCR5 Receptor Antagonists Limits: Humans Language: En Journal: Nat Prod Res Year: 2019 Document type: Article Affiliation country:
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-HIV Agents / Receptors, CCR5 / Xanthones / CCR5 Receptor Antagonists Limits: Humans Language: En Journal: Nat Prod Res Year: 2019 Document type: Article Affiliation country: