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A case of immune-mediated encephalitis related to daclizumab therapy.
Devlin, Michael; Swayne, Andrew; Newman, Martin; O'Gorman, Cullen; Brown, Helen; Ong, Benjamin; Robertson, Thomas; Airey, Caroline; Blum, Stefan.
Affiliation
  • Devlin M; Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Swayne A; Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Newman M; Mater Centre for Neurosciences, Mater Hospital, South Brisbane, QLD, Australia.
  • O'Gorman C; Faculty of Medicine, The University of Queensland, Herston, QLD, Australia.
  • Brown H; Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Ong B; Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Robertson T; Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Airey C; Princess Alexandra Hospital, Woolloongabba, QLD, Australia.
  • Blum S; Faculty of Medicine, The University of Queensland, Herston, QLD, Australia.
Mult Scler ; 25(5): 750-753, 2019 04.
Article in En | MEDLINE | ID: mdl-30073905
ABSTRACT
This report will detail a case of immune-mediated encephalitis in the context of daclizumab therapy. Daclizumab is a humanised monoclonal antibody which, prior to its recent worldwide withdrawal due to safety concerns, was utilised as a disease-modifying therapy in relapsing-remitting multiple sclerosis. The withdrawal of this therapy was prompted by concerns over 12 cases of serious immune-mediated adverse reactions in the central nervous system. We report an additional case, including clinical data and results of neuroimaging, cerebrospinal fluid (CSF) examination and brain biopsy.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Encephalitis / Antibodies, Monoclonal, Humanized / Daclizumab Type of study: Diagnostic_studies Limits: Adult / Humans / Male Language: En Journal: Mult Scler Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Encephalitis / Antibodies, Monoclonal, Humanized / Daclizumab Type of study: Diagnostic_studies Limits: Adult / Humans / Male Language: En Journal: Mult Scler Journal subject: NEUROLOGIA Year: 2019 Document type: Article Affiliation country: