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Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators.
Vaz, Roy J; Li, Yi; Chellaraj, Vinolia; Reiling, Stephan; Kuntzweiler, Theresa; Yang, Donglai; Shen, Hong; Batchelor, Joseph D; Zhang, Ying; Chen, Xin; McLean, Larry R; Kosley, Raymond.
Affiliation
  • Vaz RJ; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA. Electronic address: roy.vaz@sanofi.com.
  • Li Y; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Chellaraj V; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Reiling S; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Kuntzweiler T; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Yang D; Pre-Development Sciences, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Shen H; Pre-Development Sciences, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Batchelor JD; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Zhang Y; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Chen X; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • McLean LR; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
  • Kosley R; Integrated Drug Discovery, Sanofi US, 153-2nd Ave., Waltham, MA 02451, USA.
Bioorg Med Chem Lett ; 28(19): 3194-3196, 2018 10 15.
Article in En | MEDLINE | ID: mdl-30146095
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Cytochrome P-450 CYP3A / Pregnane X Receptor Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Country of publication:
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Metabotropic Glutamate / Cytochrome P-450 CYP3A / Pregnane X Receptor Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2018 Document type: Article Country of publication: